Bai JDK, Babu S, Roa-Peña L, et al. - Whether there exists a correlation of keratin 17 (K17) mRNA and protein levels with reduced survival of patients with high-grade endometrial cancer, was investigated. From The Cancer Genome Atlas, researchers examined gene expression data (mRNA) for 271 high-grade endometrial carcinomas. They used a separate cohort comprising 119 high-grade endometrial cancer cases from two academic medical centers in order to perform K17 immunohistochemistry (IHC). Using Cox proportional hazards regression, they determined survival analyses. Findings revealed the correlation of high K17 mRNA and IHC with decreased overall survival. Malignant glandular cells of the endometrium but not other tissues, including endometrial stroma, myometrium and uterine sarcoma, exhibited positivity for K17. In this study, K17 was identified as a negative prognostic biomarker in high-grade endometrial carcinoma, and decisions associated with treatment intervention could be assisted by K17 IHC test results.