Kwon JM, Weinreb RN, Zangwill LM, et al. - Researchers conducted this retrospective, cohort study to describe juxtapapillary (JP) and non-JP microvasculature dropout in primary open-angle glaucoma (POAG) and to compare their rate of retinal nerve fiber layer (RNFL) thinning. In total, 141 eyes with POAG with ≥ 4 serial optical coherence tomography (OCT) images after initial OCT angiography (OCT-A) for ≥ 2 years were involved. In all areas except the temporal and nasal sectors, the rate of RNFL thinning appeared to be highest in the JP group, followed by the non-JP group and no-dropout group. According to results, eyes with JP microvasculature dropout demonstrated faster RNFL thinning than eyes without dropout. Such results indicate that deep-layer microvasculature dropout, particularly in contact with the optic disc boundary, is related to rapid glaucoma progression.