Karadağ SG, et al. - In this case series of and a systematic review of the literature of cases who were male and human leukocyte antigen (HLA)-B27 negative, four cases of isotretinoin-induced sacroiliitis with changeable severity were presented and analyzed. Two individuals were responsive to baseline sulfasalazine and indomethacin treatment, whilst the other two needed more intensive treatments ie, adalimumab in one and methotrexate in the other. Fifteen articles representing 33 people (17 of whom were female) with isotretinoin-induced sacroiliitis were also distinguished. Most of them were receptive to low-to-medium doses of systemic steroids or NSAIDs. Thus, the cases demonstrate that the severity of isotretinoin-induced sacroiliitis differs from person to person.