Siroosbakht S, Rezakhaniha S, Namdari F, et al. - During the general assessment of the patients with benign prostate hyperplasia (BPH), these results should be considered. The results raise the possible hypothesis of the association between serum uric acid (UA) with international prostate symptoms score (IPSS) and PSA which should be evaluated by further trials.

• Between 2017 and 2020, this research was conducted in BPH men without cancer who were referred for annual health workup (N = 910).

• As per the findings, the mean ages were 67.28 ± 9.2 years.

• The results showed that UA was positively associated with IPSS and PSA (r = 0.210, p = .023 and r = 0.156, p = .041 respectively) and also negatively correlated with free/total PSA ratio (r = −0.332, p = .01) but not related to prostate volume (r = 0.036, p = .696).

• There were significant relationships between hyperuricemia and PSA, free/total PSA ratio, and IPSS (95% CI: 0.254–1.645, OR = 0.647, p = .039; 95% CI: 0.076–0.899, OR = 0.270, p = .033 and 95% CI: 1.011–3.386, OR = 1.851, p = .038 respectively) after adjustment for age, BMI and prostate volume.