Garritsen FM, et al. - This study probed into the occurrence of cervical carcinoma in women with atopic dermatitis (AD) treated with oral immunosuppressive drugs. It was concluded that the intensified screenings program for cervical neoplasia did not appear to be required for the study cohort.

Methods

• This study was carried out at two university medical centers in the Netherlands.
• The enrollees included were all female adult AD patients receiving oral immunosuppressive drugs (cyclosporine A, azathioprine, methotrexate, mycophenolate mofetil, enter-coated mycophenolic acid and extended release tacrolimus) for more than 2 months between 1989 and January 1st 2014.
• Screening was performed on the patient files in the national histopathology register for PAP3a, CIN I, CIN II, CIN III and cervical carcinoma.

Results

• 257 female AD patients with one or more treatment episodes from 1989 until January 1st 2014 were recruited.
• In 189 patients (73.5%) results of cervical examination were reported in the national histopathology database.
• Median total duration of therapy was 407.0 days (IQR 243.0-940.0).
• There was no report of cervical carcinoma during or following immunosuppressive therapy.