Dviri M, Madjunkova S, Koziarz A, et al. - Researchers conducted this retrospective cohort study examining whether chromosomal aberrations are linked with paternal age, via analyzing embryos derived from young oocyte donors, with available preimplantation genetic testing for aneuploidy results from day 5/6 trophectoderm biopsy obtained by next-generation sequencing for all 24 chromosomes. They allocated a total of 3,118 embryos from 407 male patients into three paternal age groups: group A, ≤ 39 years (n = 203); group B, 40–49 years (n = 161); group C, ≥ 50 years (n = 43). Inclusion was performed of 437 in vitro fertilization (IVF) antagonist cycles using 302 oocyte donors, in which preimplantation genetic testing for aneuploidy was done. In total, 70.04% of embryos were euploid, 13.9% were aneuploid, and 16.06% were mosaic. Observations revealed that after adjusting for donor, sperm, and IVF cycle characteristics, there was no correlation between paternal age and aneuploidy rates in embryos derived from IVF cycles using young oocyte donors. Compared with younger paternal ages, advanced paternal age ≥ 50, was linked with a lower fertilization rate and elevated rate of segmental aberrations.