Javidiparsijani S, Brickman A, Lin DM, et al. - In this retrospective study involving 62 patients, researchers evaluated the clinical significance of regional lymph nodes metastases in head and neck paragangliomas, a rare neoplasm of the paraganglia. Sixty-five samples were collected at a mean age of 54 (24-78 years) from patients with head and neck paragangliomas. Findings suggested that metastatic paraganglioma to regional lymph nodes may be clinically indolent, with disease-free survival of up to 11 years. The prevalence of lymph node metastatic disease was 4 (12%) of 32. Forty percent (2/5) of patients with paraganglioma sclerosing variant had lymph node metastases suggesting that the histological activity of this tumor may be more aggressive.