Is increasing paternal age negatively associated with donor oocyte recipient success? A paired analysis using sibling oocytes
Fertility and Sterility Apr 30, 2021
McCarter K, Setton R, Chung A, et al. - In this retrospective cohort study, experts aspired to explore whether increasing paternal age has an adverse effect on pregnancy outcomes in paired donor egg recipients who received oocytes from the same donor in the same stimulation cycle. The research involved 154 recipients who received oocytes from a split donor oocyte cycle and received sperm from men in discrepant age groups (group A: < 45 years old; group B: ≥ 45 years old). Group A had a median paternal age of 41 years, while group B had a median paternal age of 48 years. The pregnancy rate was 81% in group A vs 69% in group B, whereas the live birth rate was 65% in group A vs 53% in group B. Data reported that the rate of pregnancy loss was 19% in group A and 23% in group B. The authors discovered that increased paternal age had a negative impact on pregnancy rates in this model that controlled for oocyte quality to the greatest degree possible by using paired recipients from the same donor from the same stimulation cycle.
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