Mañé L, et al. – In this retrospective analysis of a prospective cohort between April 2013 and September 2015, researchers investigated the suitability of first-trimester fasting plasma glucose and HbA1c levels in non-diabetic range to identify women without diabetes at increased pregnancy risk. Upon analysis of 1,228 pregnancies, they did not identify any association between fasting plasma glucose levels and pregnancy outcomes. Women with an HbA1c ≥ 5.8% (39.9 mmol/mol) demonstrated an increased risk of macrosomia; an HbA1c ≥ 5.9% (41 mmol/mol) threshold was independently associated with a three-fold risk of pre-eclampsia and an HbA1c ≥ 6.0% (42.1 mmol/mol) with a four-fold risk of large-for-gestational age.