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Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?

BMC Endocrine Disorders Nov 05, 2021

Emilia K, Aneta S, Barbara M, et al. - Children, using modern technologies for newly diagnosed type 1 diabetes (T1D) complicated with diabetic ketoacidosis (DKA), did not exhibit deteriorated long-term metabolic control in relation to the presence of DKA at diabetes diagnosis. Continuous subcutaneous insulin infusion (CSII) could alter the impact of DKA and result in a long-term HbA 1C improvement, if it is early implemented into diabetes treatment.

  • Children treated due to newly diagnosed T1D complicated with DKA who were followed-up for 5 years were included, and in every case, individual matching was performed for age, gender and BMI with a person without DKA on recognition.

  • Presence of DKA at diabetes diagnosis was evident in 85 children at the median age of 7.93 years.

  • In each group, 87% of participants received CSII.

  • HbA 1C level did not differ (7,3%vs7,2%;p = .413) following 5 years of disease duration.

  • There was no significant impact of ketoacidosis severity on HbA 1C .

  • A significant association was found between insulin delivery method at baseline and HbA 1C levels post-5 years follow-up.

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