Matharu GS, Garriga C, Whitehouse MR, et al. - This research was attempted to compare the efficacy and safety of aspirin with direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) prophylaxis after total hip arthroplasty (THA) and total knee arthroplasty (TKA) applying the world's largest joint arthroplasty registry. Researchers examined the National Joint Registry linked to English hospital inpatient episodes for 218,650 THA and TKA patients. Individuals receiving aspirin were compared separately with patients receiving direct thrombin inhibitors and factor Xa inhibitors applying propensity scores. At 90 days, outcomes measured included VTE, length of stay, and adverse events. The data showed that DOACs were correlated with a decreased risk of VTE compared with aspirin after THA and TKA. In comparison with aspirin, DOACs were correlated with a decreased length of stay, and DOACs were not correlated with an increase in the risk of further surgery, wound problems, bleeding complications, or mortality.