Risseeuw S, Bartstra J, van Norel JO, et al. - In this cross-sectional study, experts aspired to explore if arterial stiffness was correlated with choroidal thinning in pseudoxanthoma elasticum (PXE; a rare genetic disease) patients, besides the presumed effect of Bruch's membrane (BM) calcification. The sample consisted of 75 PXE patients [median age was 58 years] and 40 controls [median age was 62 years]. Using optical coherence tomography scans, macular choroidal thickness was measured. No independent connection was found between measures of arterial stiffness and choroidal thinning in PXE patients and controls. Changes in BM probably lead to choroidal thinning in PXE.