Cherlin S, Lewis MJ, Plant D, et al. - This study was undertaken to investigate if there was any relationship between genetically regulated gene expression (as predicted using various reference panels) and anti-tumour necrosis factor (anti-TNF) treatment response (change in erythrocyte sedimentation rate using 3,158 European ancestry patients with rheumatoid arthritis. Researchers calculated a genetically regulated portion of gene expression in the full cohort of 3,158 individuals (as well as within a subcohort consisting of 1575 UK patients) applying the PrediXcan software package with three different reference panels. They evaluated estimated expression for the relationship with anti-TNF treatment response. The data imply that Interleukin 18 Receptor Accessory Protein expression is worthy of further evaluation as a potential prognosticator of treatment response in rheumatoid arthritis that is not specific to a particular drug type.