Speed MS, et al. - Researchers undertook a Mendelian randomization study of the association between fat mass, nonfat mass, height, and depression in order to better appreciate the association between obesity and depression. For this study, they used genome-wide association study results from the UK Biobank (n = 332,000) and the Psychiatric Genomics Consortium (n = 480,000). Findings suggest the causative role of both fat mass and height (short stature), but not nonfat mass, in depression. These results provide significant novel insight into the role of anthropometric measures in the etiology of depression. Further, they suggested that the risk of depression may decrease with reducing fat mass, thereby providing further backing to public health measures intended at decreasing the obesity epidemic.