Assouline B, Benoliel A, Zamberg I, et al. - Researchers examined how intravenous iron administration in the immediate postoperative period affects anemia and iron status as well as investigated the kinetics of hepcidin after liver surgery. In the HepciFer trial, a randomized controlled trial, 50 patients undergoing liver surgery were administered either ferric carboxymaltose (15 mg/kg, maximum 1 g) or placebo 4 hours after surgery in accordance with the randomization process. Outcomes revealed no significant increase of hemoglobin levels 7 days after surgery in correlation with providing intravenous ferric carboxymaltose administration. However, this study suggests prevention of functional iron deficiency because of intravenous iron supplementation in the immediate postoperative settings. The hepcidin-mediated blockade of iron absorption was overcome with intravenous iron supplementation and hence they support considering this as the preferred route of administration in the postoperative period.