Tammachote N, et al. - Via conducting a randomized, double-blind, placebo-controlled trial, researchers sought to ascertain the analgesic effects of intravenous (IV) dexamethasone (DEX) in patients undergoing total knee arthroplasty (TKA). Administration of either 0.15 mg/kg of IV DEX or saline placebo was done in participants (50 patients/arm) in unilateral TKA. They identified a significantly lower mean visual analog scale score in the DEX group both at rest and during motion at 12, 15, 18, and 21 hours. Mean morphine consumption did not differ significantly by 48 hours; no significant differences were evident in modified Western Ontario and McMaster University Osteoarthritis Index scores, and range of motion of the knee at a 3-month follow-up. These findings suggest that postoperative pain between 12 to 21 hours after TKA could be relieved using IV DEX and it may be a valuable adjunct for managing pain in patients undergoing TKA.