Sharpe EE, Molitor RJ, Arendt KW, et al. - Since no prospective investigations have compared the effectiveness of equipotent doses of intrathecal morphine vs intrathecal hydromorphone as part of a multimodal analgesic regimen for pain relief after cesarean, researchers undertook this single-center, double-blinded, randomized trial to investigate whether intrathecal morphine affords superior analgesia vs intrathecal hydromorphone 24 h post-delivery. Random allocation of 138 parturients undergoing scheduled cesarean delivery was done to receive 150 µg of intrathecal morphine or 75 µg of intrathecal hydromorphone as part of a primary spinal anesthetic and multimodal analgesic regimen; 134 parturients were involved in this study. Experts noted that pain scores with movement did not differ significantly, at 24 h or at any time point. The findings did not corroborate the hypothesis that intrathecal morphine would afford superior pain relief than intrathecal hydromorphone. Experts found that effective postcesarean analgesia was afforded by both intrathecal morphine and intrathecal hydromorphone, at the doses studied, when integrated with a multimodal analgesia regimen.