Silverton NA, Hall IE, Melendez NP, et al. - Researchers undertook this prospective, nonrandomized, observational analysis to determine the link between intraoperative urinary biomarker excretion during cardiac surgery and the subsequent occurrence of acute kidney injury (AKI). This study involved 90 patients receiving cardiac surgery with cardiopulmonary bypass (CPB). Every 30 minutes intraoperatively as well as at 4, 12, and 24 hours post-CPB, urinary samples were obtained. Experts analyzed these samples for interleukin-18 (IL18), kidney injury molecule-1 (KIM1), and creatine levels. During intraoperative and postoperative time points, greater AKI incidence and longer intensive care and hospital length of stay were reported in patients in the fourth quartile of KIM1 excretion vs those in the first quartile. Overall, findings revealed that intraoperative KIM1 but not IL18 excretion was related to AKI occurrence after surgery.