Dang VQ, Vuong LN, Luu TM, et al. - Since the use of intracytoplasmic sperm injection has increased significantly around the world, primarily in couples with non-male factor infertility, however, there is a scarcity of evidence from randomized trials supporting this approach compared with conventional in-vitro fertilisation (IVF), researchers conducted this open-label, multicentre, randomised trial to ascertain if intracytoplasmic sperm injection would result in a higher livebirth rate compared with conventional IVF. This trial was carried out at two IVF centres in Ho Chi Minh City, Vietnam (IVFMD, My Duc Hospital and IVFAS, An Sinh Hospital). One thousand sixty-four couples were randomly assigned to intracytoplasmic sperm injection (n = 532) or conventional IVF (n = 532) between March 16, 2018, and August 12, 2019. When compared with conventional IVF, intracytoplasmic sperm injection did not improve the livebirth rate in couples with infertility where the male partner had a normal total sperm count and motility. The findings call into question the value of routine intracytoplasmic sperm injection in assisted reproduction techniques for this population.