Colen S, Hoorntje A, Dalemans A, et al. - In this study, the influence of intra-articular hyaluronic acid (IAHA) on the outcome of total hip arthroplasty (THA), with an emphasis on the periprosthetic joint infection (PJI) was evaluated. Researchers compared complication rates, including superficial and deep PJIs, of THA in patients who received an IAHA injection ≤ 6 months prior to surgery (injection group) with that of patients undergoing THA without any previous injection in the ipsilateral hip (control group) at a mean follow-up of 52 months (±18). Researchers retrospectively enrolled 113 patients (118 hips) in the injection group and 452 patients (495 hips) in the control group. The data revealed that IAHA conducted 6 months or less prior to THA may pose a risk for elevated rates of PJI. After IAHA administration, they recommend refraining from conducting THA within 6 months.