Wang Q, et al. – The physicians aimed to investigate the interaction between FKBP5 gene variants and early–life stress and their relationship with stress–related disorders such as major depression and PTSD through a systematic review and meta–analysis. They suggested evidence of interactions between FKBP5 genotypes and early–life stress, which could pose a significant risk factor for stress–associated disorders such as major depression and PTSD.

Methods

• Using PsychINFO and PubMed databases, a literature search was conducted until May, 2017.
• An aggregate of 14 studies with a pooled total of 15109 members met the inclusion criteria, the outcomes of which were combined and a meta-analysis was performed using the differences in correlations as the effect measure.
• Based on literature, rs1360780, rs3800373, and rs9470080 SNPs were chosen within the FKBP5 gene and systematic review was conducted.

Results

• No publication bias was detected based on the Comprehensive Meta-Analysis software.
• In addition, sensitivity analysis and credibility of meta-analysis results demonstrated that the analyses were stable.
• The meta-analysis demonstrated that people who carry T allele of rs1360780, C-allele of rs3800373 or T-allele of rs9470080 exposed to early-life trauma had higher risks for depression or PTSD.