Singh N, et al. - Researchers performed a meta-analysis of 31 randomized trials with a 20,816 overweight or obese participants to assess the significance of the frequency and duration of lifestyle interventions for achieving weight loss over ≥ 1 year. Furthermore, they investigated their associations with all-cause mortality. Outcomes revealed a dose-response relationship between the number of lifestyle interventions and weight loss in predominantly healthy populations with risk factors. Hence, clinically meaningful weight loss could be achieved in correlation with lifestyle programs with frequent patient interactions sustained over a year or more, and during long term follow-up, this may lower mortality. However, there appeared more modest benefits in body weight and there were uncertain long-term benefits to mortality risk in correlation with less frequent interventions over shorter durations.