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Intellectual disability in children conceived using assisted reproductive technology

Pediatrics Dec 14, 2018

Hansen M, et al. - The authors examined 210,627 live births by using Poisson regression with robust SEs from 1994 to 2002 (with at least 8 years of follow-up) in Western Australia to analyze if children conceived using assisted reproductive technology (ART) had a raised risk of intellectual disability (ID) in comparison to non–ART-conceived infants and estimated the known causes of ID in those groups. They found offsprings conceived using ART had a small increased risk of ID even in cases of singleton births and doubled for those born very preterm, for severe ID, and after intracytoplasmic sperm injection (ICSI) treatments. They also observed a higher risk of ID in children conceived using ICSI than those conceived using in vitro fertilization. Infants conceived using ICSI were found more suitable to have a known genetic cause for ID.
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