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Intact global cognitive and olfactory ability predicts lack of transition to dementia

Alzheimer's and Dementia Nov 07, 2019

Devanand DP, Lee S, Luchsinger JA, et al. - Via analyzing data from 749 candidates followed up for 4 years, researchers ascertained whether intact performance on brief cognitive and odor identification tests anticipates a lack of transition to dementia. The 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT), was completed in an urban community by 1,037 older adults without dementia. Impairment of the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109) in covariate-adjusted survival analyses, primarily Alzheimer disease (n = 101). Among candidates with intact olfactory (B-SIT ≥ 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test ≤ 5/28 incorrect) ability, 3.4% (4/117) transitioned to dementia in the 70–75 and 81–83 years age group quartiles during follow-up with no transitions. Findings suggested that monitoring for odor detection adds value to global cognitive testing and together can identify people who often transition to dementia while avoiding unnecessary diagnostic investigation.
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