Markoska A, et al. - Authors sought to inspect the urinary C peptide creatinine ratio (UCPCR) used in a modified Matsuda equation with the intention of estimating insulin sensitivity (IS) in pregnancy. Data shed light on the connection between the IS measured using serum C peptide (IS_OGTTc-pep) in the modified Matsuda equation with the IS measurement using serum UCPCR. Findings illustrated a strong link between the IS_OGTT-UCPCR and the fasting UCPCR, exhibiting a hyperbolic relationship. The inference drawn was that UCPCR provided a practical methodology to analyze IS and β-cell function in pregnancy.