Vajgel G, Oliveira CBL, Costa DMN, et al. - Overall, 280 outpatients with a diagnosis of SLE and prior kidney biopsy of lupus nephritis were enrolled from August 2015 to December 2018 in order to baseline and follow-up features associated with poorer renal outcomes in a Brazilian cohort of admixture race individuals with lupus nephritis. Adjusted logistic regression analysis exhibited that predictors of progressive chronic kidney disease were class IV lupus nephritis and interstitial fibrosis ≥ 25% at initial biopsy, lack of complete or partial response at 12 months, and a second renal flare. In a Kaplan-Meier survival curve, it was discovered that across the follow-up, class IV lupus nephritis and interstitial fibrosis ≥ 25% were notably correlated with end-stage kidney disease. In this large cohort of admixture race patients, class IV lupus nephritis and chronic interstitial damage at initial renal biopsy together with non-response following 1 year of therapy and relapse were related to worse long-term renal outcomes.