Khalid MB, et al. - Because human papillomavirus (HPV) is considered a risk factor for oropharyngeal squamous cell carcinoma (OPSCC) as well as a reason for the current drastic increase in the incidence of this disease, researchers described common presenting signs of HPV-positive OPSCC in this retrospective review. The study sample consisted of 370 subjects treated for OPSCC between April 2007 and November 2015 at the Icahn School of Medicine in Mount Sinai, New York City. The final analysis included patients with newly diagnosed OPSCC and adequate history and physical data. The inclusion criteria were met by 207 patients. By 2020, HPV-positive OPSCC could surpass cervical cancer as the most common cancer associated with HPV, according to these results. HPV-positive status was associated with a positive neck examination. Initial presenting signs may commonly be incorrectly considered benign processes. Neck mass and sore throat were the most common initial symptoms for OPSCC.