Wang S, Zhang Y, Liu Y, et al. - Researchers investigated the role of cysteine and glycine-rich protein 2 (CSRP2) in predicting adult acute myeloid leukemia (AML) recurrence. This study included 193 newly diagnosed adult AML patients and 44 healthy controls. In participants, the expression of CSRP2 was assessed using RT-PCR. In patients vs controls, higher CSRP2 transcript levels were detected. A total of 149 patients achieved complete remission, among these, a lower 2-year cumulative incidence of relapse rate and higher 2-year relapse-free survival rate (RFS) were seen in those with high CSRP2 transcript levels, particularly when receiving only chemotherapy. Multivariate analysis revealed an independent correlation of a high CSRP2 transcript level with a better RFS. Overall, findings revealed a correlation of CSRP2 with relapse in adult AML. CSRP2 down-regulation resulted in regulation of AKT and CREB signaling pathways which encouraged proliferation of AML cell lines. Thus, experts inferred that CSRP2 may afford prognostic significance as well as potential treatment targets in the management of AML.