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Influence of timeliness and receipt of first treatment on geographic variation in non‐small cell lung cancer mortality

International Journal of Cancer Oct 26, 2020

Wah W, Stirling RG, Ahern S, et al. - In patients suffering from non‐small cell lung cancer (NSCLC), researchers assessed the independent as well as the relative contribution of the individual‐ and area‐level risk factors on geographic difference in 2‐year all‐cause mortality. For this purpose, they employed the Bayesian spatial multilevel logistic regression model in the Hierarchical‐related regression approach.  Individual‐level data included 3,330 NSCLC cases between 2011 and 2016 from the Victoria Lung Cancer Registry. After looking at significant individual‐ and area‐level risk factors, a lower probability of NSCLC 2‐year all‐cause mortality was linked to factors such as timely (≤ 14 days) first definitive treatment and multidisciplinary meetings (MDM). A greater likelihood of 2‐ and 5‐year all‐cause mortality was independently linked to timely and delayed (>14 days) first nondefinitive treatment, no treatment, advanced clinical stage, smoking, poor performance status, public hospital insurance, and area‐level deprivation. It was emphasized that the first definitive treatment should be received by NSCLC patients within the recommended 14‐days from diagnosis.

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