Potter KJ, Boudreau V, Shohoudi A, et al. - A landmark study highlighted the clinical deterioration in respiratory function and nutritional status prior to the onset of cystic fibrosis-related diabetes (CFRD) in 1992. This outcome was reevaluated. Researchers conducted the Montreal Cystic Fibrosis Cohort that was a prospective CFRD screening study performing a 6-year retrospective analysis of nutritional parameters and FEV₁ (%) in individuals who developed incident CFRD and in controls who maintained normoglycemia. Data were obtained over 6 years prior to diabetes onset in the former group. The study included a total of 86 individuals. The results indicated that CFRD onset is not preceded by deterioration in BMI, fat mass, or pulmonary function in a contemporary context. Compared with a pre-diabetic state, low BMI and FEV₁ are more closely correlated with pancreatic insufficiency.