Tang Y, et al. – This systematic review strived to investigate the efficacy of greater occipital nerve (GON) block in migraine patients. GON block intervention could significantly alleviate pain, reduce the number of headache days and medication consumption compared to control intervention, however, demonstrated no influence on duration of headache per 4 weeks for migraine patients.

• The authors systematically searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases.
• They included randomized controlled trials (RCTs) assessing the efficacy of GON block versus placebo in migraine patients.
• For this study, 2 investigators independently searched articles, extracted data, and evaluated the quality of included studies.
• Using the random-effect model, meta-analysis was performed.

• The authors included 6 RCTs in the meta-analysis.
• GON block intervention was found to significantly reduce pain score (Std. mean difference = -0.51; 95% CI = -0.81 to -0.21; P = 0.0008), number of headache days (Std. mean difference = -0.68; 95% CI = -1.02 to -0.35; P < 0.0001), and medication consumption (Std. mean difference = -0.35; 95% CI = -0.67 to -0.02; P = 0.04) compared with control intervention in migraine patients, but demonstrated no influence on duration of headache per four weeks (Std. mean difference = -0.07; 95% CI = -0.41 to 0.27; P = 0.70).