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Influence of early-onset peritonitis on mortality and clinical outcomes in ESRD patients with diabetes mellitus on peritoneal dialysis: A retrospective multicenter study

Blood Purification Oct 15, 2021

Guo Q, Chen Y, Yang L, et al. - In patients with diabetes receiving peritoneal dialysis (PD), early-onset peritonitis (EOP) occurrence was significantly related to lower rates of PDAP(peritoneal dialysis-related peritonitis)-associated death and poorer clinical results.

  • This is a retrospective cohort study of 202 patients with end-stage renal disease, who were also suffering from diabetes mellitus and had received PD.

  • Participants were split into an EOP group and a later-onset peritonitis (LOP) group.

  • In the EOP group, a less chance of occurrence of PDAP-related death (OR 0.13) was observed in patients with diabetes.

  • Diabetic patients in the EOP group had greater probability of encountering multiple episodes of PDAP and had higher rates of technical failure and poorer patient survival, compared with those in the LOP group.

  • Multivariate Cox proportional hazards model demonstrated EOP as a significant predictor for multiple PDAP (HR 4.20), technical failure (HR 6.37), and poorer patient survival (HR 3.09).

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