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Influence of early-life parental severe life events on the risk of type 1 diabetes in children: The DiPiS study

Acta Diabetologica May 17, 2018

Lundgren M, et al. - Using data from the prospective Diabetes Prediction in Skåne (DiPiS) study, researchers ascertained whether stress and severe life events (SLEs) reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D). To calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population, a Cox proportional hazards model was used. In this analysis, prospective questionnaire data recorded at 2 months and 2 years of age from the DiPiS cohort of children were involved. The findings from the present study suggested that children of parents experiencing an SLE during the child’s first 2 years of life were at increased risk of T1D.
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