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Influence of changes in soft tissue composition on changes in bone strength in peripubertal girls: The STAR longitudinal study

Journal of Bone and Mineral Research Sep 19, 2020

Bland VL, Bea JW, Blew RM, et al. - In the present study, the researchers sought to evaluate how changes in DXA‐derived total body lean mass (TBLM) and total body fat mass (TBFM) contribute to 2‐year changes in bone outcomes at the 20% femur, 66% tibia, 66% radius, and 4% tibia, as measured by pQCT, during the years surrounding the onset of menarche in a cohort of 9‐ to 12‐year‐old (baseline) adolescent girls (70% Hispanic). Girls showed statistically significant increases in all bone outcomes from baseline to 2‐year follow‐up, except radial endosteal circumference. The overall results indicate that changes in TBLM have a greater influence on bone outcomes during the peripubertal years than changes in TBFM. Although gains in TBFM may support weight-bearing 66% tibia, higher gains in TBFM may be detrimental to bone development at the non‐weight bearing 66% radius after the onset of menarche. 

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