Yu JL, Liu Y, Tangutur A, et al. - Given the association of lower therapeutic positive airway pressure (PAP) levels with improved response to non-PAP therapies in the treatment of obstructive sleep apnea (OSA), researchers herein evaluated the prevailing notion that patients with apnea-predominant OSA necessitate higher therapeutic PAP levels compared with patients with hypopnea-predominant OSA. They used strict inclusion criteria (presence of Type I or III sleep study, AHI > 10events/h, adherence to Auto-CPAP) to conduct an IRB-approved retrospective review. Among 500 patients meeting inclusion criteria, 221 (44.1%) patients were apnea predominant and 279 (55.8%) were hypopnea predominant. A clinically insignificant difference in PAP level was observed between apnea predominant individuals and hypopnea predominant individuals; in addition, there was no strong predictive value of obstructive apnea percentage for therapeutic PAP levels. Of the modeled variables, AHI was the strongest predictor of PAP level.