Counotte J, et al. - Researchers sought to enhance their understanding regarding the association between childhood trauma, inflammation, and psychosis. Among 40 patients with recent onset psychosis, 13 patients at ultra-high risk for psychosis, 31 unaffected siblings of psychosis patients, and 41 healthy controls, they examined serum levels of brain-derived neurotrophic factor, chemokine ligand-2, C-reactive protein, interferon (IFN)-γ, insulin-like growth factor binding protein, interleukin (IL)-6, platelet-derived growth factor, stem cell factor, and tumor necrosis factor-α in correlation to psychosis liability and childhood trauma, separately and in combination. Using the Childhood Trauma Questionnaire, they assessed childhood trauma retrospectively. Findings revealed no statistically significant impact of psychosis liability or childhood trauma on concentrations of cytokines or growth factors in peripheral blood. There were also no statistically significant effects of psychosis liability with childhood trauma on serum levels of cytokines and growth factors.