MacEachern DB, et al. - In women with epilepsy (WWE) in the United States, researchers determined the contemporary risks of infertility and impaired fecundity and the ratio of live birth/pregnancy and if the use of an antiepileptic drug (AED) has any impact. Data from the 2010-2014 Epilepsy Birth Control Registry (EBCR) Web-based survey of 1,000 WWE in the United States, aged 18 to 47 years was included, providing demographic, epilepsy, AED, reproductive, and contraceptive information. A total of 978 of the 1,000 US WWE reported reproductive data and an additional 38 WWE tried to conceive but were infertile. According to findings, the EBCR identifies an infertility risk of 9.2% and a risk of impaired fecundity of 20.7% among WWE in the US. On AED polytherapy, impaired fecundity tended to be higher than on no AED. With the use of lamotrigine, the live birth/pregnancy ratio was greater than valproate. These findings can provide a more objective basis for the planning of pregnancy for WWE.