Depuydt CE, et al. - Researchers performed this prospective noninterventional multicenter study in order to assess how human papillomavirus (HPV) virions present in different sperm fractions of male partners of women undergoing IUI influence fertility outcome. From 732 infertile couples undergoing 1,753 IUI cycles with capacitated sperm, they enrolled 573 infertile couples undergoing 1,362 IUI cycles. Eighteen different HPV types (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, and 68) were tested using quantitative polymerase chain reaction in IUI generated 3,444 separate sperm fractions from 1,362 sperm samples. Observations revealed 4 times fewer clinical pregnancies among women inseminated with HPV-positive sperm compared to women who had HPV-negative partners. A negative IUI outcome was noted in correlation to the detection of HPV virions in sperm and hence they recommend including it in routine examination and counseling of infertile couples.