Günzel K, Magheli A, Baco E, et al. - The present study was performed to evaluate the post-biopsy infection rate, feasibility, and prostate cancer detection rate by performing transperineal MRI-Transrectal ultrasound (TRUS) fusion biopsy of the prostate (TPBx) under local anesthesia (LA) without antibiotic prophylaxis (AP). Between May 2019 and July 2020, researchers prospectively screened 766 men with suspicious lesions on mpMRI, an elevated prostate-specific antigen (PSA) level, or a suspect digital examination undergoing MRI-TRUS-TPBx in LA. In this study, 621 patients with a median age of 68 years were included (IQR 62–74), a PSA of 6.43 ng/mL (IQR 4.72–9.91), and a prostate volume of 45 ccs (IQR 32–64). The data indicate that transperineal MRI-TRUS fusion-guided prostate biopsy under LA without AP is feasible, safe, and well-tolerated.