Alkmark M, Keulen JKJ, Kortekaas JC, et al. - A gradual increase in the risk of perinatal death and severe neonatal morbidity has been observed after 41 weeks of pregnancy, researchers here conducted an individual participant data meta-analysis (IPD-MA) with the aim to assess if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. They recognized three RCTs including a total of 5,161 women with low-risk singleton pregnancies that compared IOL at 41 gestational weeks with expectant management until 42 gestational weeks. For inclusion in an IPD-MA, there was availability of data of two RCTs with a total of 4,561 women. Overall findings revealed significant reduction in the composite outcome of perinatal mortality and severe neonatal morbidity, and perinatal mortality alone in correlation with induction at 41 gestational weeks, with no increase in the risk of cesarean delivery, operative vaginal delivery, perineal lacerations III and IV, or postpartum haemorrhage. However, there remains uncertainty concerning the magnitude of the risk of perinatal mortality. A prespecified subgroup analysis indicates that nulliparous but not multiparous women exhibit significantly decreased risk of composite severe adverse perinatal outcome in the IOL group.