Induction of labor with a Foley catheter and the risk of subsequent preterm birth: A follow‐up study of two randomized controlled trials (PROBAAT‐1 and ‐2)
Ultrasound in Obstetrics & Gynecology Sep 30, 2020
de Vaan MDT, Blel D, Bloemenkamp KWM, et al. - Preterm birth rate in a subsequent pregnancy was examined among women who had undergone term induction with a Foley catheter vs those who underwent induction with prostaglandins. Researchers conducted a follow‐up study of two large randomized controlled trials. In the original trials (PROBAAT‐1 and PROBAAT‐2), randomization of women with a term, singleton pregnancy in cephalic presentation with an indication for labor induction was done to either a 30cc Foley catheter or prostaglandins (i.e. vaginal prostaglandin E2 in PROBAAT 1 and oral misoprostol in PROBAAT 2). A subsequent pregnancy beyond 16 weeks gestation was reported in 251 of 572 women randomized to a Foley catheter vs 258 of the 570 women who received prostaglandins. Women with a singleton term pregnancy who underwent induction of labor with a 30cc Foley catheter were not noted to be at increased risk for preterm birth in a subsequent pregnancy relative to those who had induction of labor with prostaglandins.
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