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Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma

Cancer Medicine Jun 16, 2021

Lake CM, Bondoc AJ, Dasgupta AR, et al. - Difficulties are encountered in identification of the margins of a cancer for removal or distant disease that has spread and fluorescent dye has been investigated as a way for improving identification of disease. Hepatoblastoma is identified to be the most common pediatric liver cancer. Researchers herein aimed at determining the utility of indocyanine green (ICG) as an adjunct to resection in a large cohort of patients diagnosed with hepatoblastoma. They retrospectively reviewed records for 29 patients diagnosed with hepatoblastoma who received ICG prior to surgical resection. Findings support the utility of ICG as a sensitive adjunct for depicting local and metastatic hepatoblastoma, including lesions not seen on preoperative imaging, and defining margins during liver resection. Specificity is limited by false positives; however, no adverse outcomes were reported in correlation with additional resections. They identified that safe competition of thoracoscopic surgery can be done in patients with less significant disease burden, and conversion to thoracotomy, if required, is straightforward.

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