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Individualized significance of 24-hour intraocular pressure curves for therapeutic decisions in primary chronic open-angle glaucoma patients

Clinical Ophthalmology May 31, 2020

Lever M, Unterlauft JD, Halfwassen C, et al. - Researchers conducted this retrospective analysis to assess the effect of individual patient characteristics and glaucoma-related parameters on therapy decisions after intraocular pressure curves (IPC) and thus investigate their relevance for glaucoma management. The sample consisted of adult primary open-angle glaucoma (POAG) patients who had an IPC (≥ 6 IOP measurements in 24 hours). Participants in the study were 101 patients (101 eyes). Regression analysis outcomes indicated a predictive role of IPC-independent parameters for IPC therapeutic decisions. IPC-independent parameters did not correlate with therapeutic decisions after IPC in subgroups of patients of older age or advanced glaucoma. Such findings support the relevance of IPC in the therapeutic management of POAG. In addition , the research supports a personalized classification of patients using identified glaucoma characteristics to objectivize their individual benefit from IPC.

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