Loh WJ, et al. - In this investigation, researchers ascertained if regional fat masses and insulin sensitivity are independently associated with bone mineral density (BMD). Using the intravenous glucose tolerance test, they assessed associations between total and regional body fat, insulin sensitivity, and measures of BMD in eight different regions in a cross-section of 590 generally healthy, white males—274 of whom received the measurement of insulin sensitivity (Si). To explore associations with each regional BMD, linear regression analyses were combined in mediation analysis. Investigators found that weight correlated with total fat mass positively and, with Si, negatively. Findings suggested that android fat has a negative independent association with BMD spine. Increased insulin sensitivity was found to be correlated with higher limb BMD among those who exercise, and might be related to positive associations between lean body mass and BMD.