Lyu Z, et al. - Via performing this study with a cohort of 109,798 males with baseline data on total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL levels, researchers examined the independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males. They prospectively observed these males from 2006 to 2015 for cancer incidence. They identified a total of 986 lung cancer cases during a 9-year follow-up period. In multivariable analyses, an increased lung cancer risk was noted in both males with low TC and males with high TC levels, and in restricted cubic spline (RCS) analysis, a U-shaped association was suggested. Furthermore, increased lung cancer risk was noted in correlation with both low TG and high TG levels, and with low LDL-C levels. Upon considering TC, TG, and LDL-C jointly, the investigators observed the linear association of the number of abnormal indicators with an increased risk of lung cancer, as subjects with three abnormal indicators had a two-fold higher risk of developing lung cancer. Interestingly, these associations were found to be statistically significant among never-smokers, never-drinkers, and overweight/obese males.