Cheslack-Postava K, et al. - Using data from an annual, nationally representative, cross-sectional study, the National Survey on Drug Use and Health, researchers performed this investigation in 2018 and 2019, to determine the prevalence as well as trends over time in depression (2005–2016), marijuana use (2002–2016), and alcohol use problems (2002–2016) among former US smokers (aged ≥ 18 years). Having smoked ≥ 100 lifetime cigarettes and no preceding-year cigarettes defined former smokers. Over time rise in the prevalence of depression and substance use, which are factors related to a heightened risk for cigarette use relapse, was reported among former US smokers. An increase in major depression prevalence from 4.88% to 6.04% was seen from 2005 to 2016. A rise from 5.35% to 10.09% in past-year marijuana use was also documented from 2002 to 2016. An increase from 17.22% to 22.33% was noted in past-month binge alcohol use, although no alteration was evident in the prevalence of past-year alcohol abuse or dependence.