Petrakis G, Veloza L, Clot G, et al. - Fifty-six patients diagnosed with mantle cell lymphoma (MCL), of whom 38 were sex-determining region-Y-box11 (SOX11)-positive and 18 were SOX11-negative, were examined to assess the development of microvascular angiogenesis in primary MCL in association with SOX11 expression and its potential prognostic ability. Significantly higher microvascular development was exhibited by SOX11-positive MCL vs negative tumors. A high microvessel density (MVD) was related to shorter OA; a comparable inclination was recognized for the high microvascular area (MVA) on analyzing the MVA and MVD as consecutive variables. The microvascular development was not associated with the Ki-67 proliferative index or 17p/TP53, 9p or 11q alterations. In conclusion, in primary MCL, an angiogenic phenotype is promoted by SOX11, which may play a part in the more aggressive nature of these tumors.