Korb D, Schmitz T, Seco A, et al. - Researchers here examined if the risk of serious maternal complications during pregnancy and the postpartum in twin pregnancies differs according to mode of conception: natural conception, non-IVF fertility treatment, IVF, ICSI or oocyte donation. They conducted a secondary analysis of the national, observational, prospective, population-based cohort study of twin pregnancies (JUmeaux Mode d’Accouchement), which took place in France from February 10, 2014 through March 1, 2015. They assessed 8,748 women with a twin pregnancy who gave birth at or after 22 weeks of gestation. Among these, 5,890 (67.3%) conceived naturally, 854 (9.8%) had non-IVF fertility treatment, 1,307 (14.9%) had IVF with autologous oocytes, 368 (4.2%) had ICSI with autologous oocytes and 329 (3.8%) used oocyte donation. Severe acute maternal morbidity developed in 538 (6.1%) of these women. Per findings, there was overall 30% higher risk of serious maternal complications among women with twin pregnancies after medically assisted reproduction (MAR) compared with women with natural twin pregnancies. This link was observed to vary in accordance to the MAR procedure; the risk was increased by 50% with IVF using autologous oocytes and by 270% with oocyte donation.