de Wilde MA, et al. – In this research, analysts study the presence of several maternal and neonatal complications in a cohort of women with hyperandrogenic and also normoandrogenic polycystic ovary syndrome (PCOS) and women with PCOS who received different fertility treatments. Based on these outcomes, women with PCOS have an increased risk of maternal and neonatal pregnancy complications, especially women with the hyperandrogenic phenotype.

Methods

• For this research, they designed a prospective multicenter cohort study.
• This study was conducted in Hospitals and midwifery practices.
• In this study, they enrolled 188 women with PCOS and singleton pregnancies (study group) and 2,889 women with a naturally conceived singleton pregnancy (reference group).

Results

• In this study, they observed women with PCOS had a statistically significantly increased risk of developing gestational diabetes (adjusted odds ratio [AOR] 4.15; 95% confidence interval [CI], 2.07–8.33) compared with the reference group, and their infants were more often born small for gestational age (AOR 3.76; 95% CI, 1.69–8.35).
• In a subgroup examination, maternal complications were statistically significantly more often present in women with hyperandrogenic (characterized as a free androgen index >4.5) PCOS (n = 76; 40% of all PCOS women) compared with those with normoandrogenic PCOS (n = 97; 52% of all PCOS women) (45% vs. 24% P=.003); no statistically significant differences were seen between these groups regarding with respect to complications.