Narváez J, LLuch J, Ruiz-Majoral A, et al. - This case-control analysis was conducted to determine the prevalence, severity, as well as related clinical factors of mitral and aortic valvular involvement in patients suffering from systemic sclerosis (SSc). Participants included 172 patients experiencing SSc and 172 non-SSc adults without known cardiac disease matched by age, gender, and prevalence of cardiovascular (CV) risk factors. Separate study of different types of valvular lesions revealed a significantly higher frequency of mitral regurgitation (MR) vs controls, and also 65–75 and 76–85 age groups had a higher frequency of aortic stenosis (AS) vs general population in the community. Findings showed that SSc patients, vs age-matched non-SSc controls with similar CV comorbidities, had an increased prevalence of moderate to severe MR as well as AS. While findings did not permit for establishing a direct causal association, the contribution of SSc-specific factors in the occurrence of these complications was strongly supported.